Endocrine Abstracts

Introduction: Podoplanin (PDPN) is a transmembrane protein linked with metastases of various cancers, including papillary thyroid carcinoma (PTC). PDPN is significantly upregulated in PTC specimens and PTC- derived cell lines: TPC1 and BCPAP, harboring RET/PTC and BRAF V600E alterations, respectively. We observed that depletion of PDPN impairs migration of TPC1 cells, but surprisingly, augments metastases of BCPAP cells. To elucidate this phenomenon we aimed to further investi...